Blue Gender takes place in the not too distant future in a world where things have gone terribly wrong for humanity. Humans have been replaced at the top of the food chain by the Blue, a race of bug-like aliens that have colonized Earth and pushed humans aside. A space station, Second Earth, has been constructed as a safe haven for humans, with the hope of one day reclaiming the Earth once more.

Yuji Kaido was cryogenically frozen, having been suffering from a disease known as B-Cells. Once awakened, he joins a team of soldiers that have come to Earth to extract him. Unfortunately, nothing goes according to plan as they make their way back to Second Earth.

Yuji will have to deal with the horrors of fighting a bloody war as he and the fighters from Second Earth look to survive. Will they be able to win back Earth without losing their humanity?

It is a time of chaos. Earth is no longer what it used to be. It has been infested with a bug like species called the Blue. 20 years ago Yuji Kaido, who has a mysterious disease, is put into suspended animation until a cure is found. When he wakes up Yuji learns that it’s been more than 20 years since he was put into suspended animation, and the world is now controlled by these creatures. He then decides to join a group of soldiers fighting against the Blue for hope of a better future.

[Source: Anime News Network]