Hiroshi was ordered to collect the fruit of cactus and was transferred to Mexico. So, Nohara family had to move to Mexico and live there. They had to bid farewell to their acquaintances and the citizens of Kasukabe with tears. Shinnosuke had heard that Mexican young girls are stylish and beautiful, so he was eager for this journey. On arriving at Madakueruyobaka city in Mexico, a new life full of anxiety, surrounded by unique neighbors, is awaiting them. But Shinnosuke and Nohara Family had no idea that flesh-eating killer cactuses are going to attack. Can Nohara Family, along with the neighbors of Mexico really overcome this trouble?